N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5S)-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(2-pyridinylmethyl)urea

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5S)-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-3-pyridinylurea

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-4-pyridinecarboxamide

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5S)-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-4-pyridinecarboxamide

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(4-pyridinylmethyl)urea

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5S)-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(4-pyridinylmethyl)urea

N-[(3R)-1-[6-[[2,2-Bis(4-methoxyphenyl)ethyl]amino]-9-[(2R,3R,4S,5S)-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-6-[(1-naphthalenylmethyl)amino]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

4-[2-[[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-2-[(3R)-3-[[[(3R)-3-pyrrolidinylamino]carbonyl]amino]-1-pyrrolidinyl]-9H-purin-6-yl]amino]ethyl]benzenesulfonamide

N-[(3R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-6-[(9H-fluoren-9-ylmethyl)amino]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-6-[(1-naphthalenylmethyl)amino]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[6-[[2,2-Bis(4-methoxyphenyl)ethyl]amino]-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[6-[(1-Ethylpropyl)amino]-9-[(2R,3R,4S,5R)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[9-[(2R,3R,4S,5R)-5-(2-Ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-dihydroxy-2-furanyl]-6-[[(1S)-1-(hydroxymethyl)-2-phenylethyl]amino]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[6-[(2,2-Diphenylethyl)amino]-9-[(2R,3R,4S,5S)-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-6-[(1-ethylpropyl)amino]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

N-[(3R)-1-[9-[(2R,3R,4S,5S)-5-(3-Ethyl-5-isoxazolyl)tetrahydro-3,4-dihydroxy-2-furanyl]-6-[[(1S)-1-(hydroxymethyl)-2-phenylethyl]amino]-9H-purin-2-yl]-3-pyrrolidinyl]-N′-(3R)-3-pyrrolidinylurea

(2R,3R,4S,5S)-2-[6-[[2,2-Bis(4-methoxyphenyl)ethyl]amino]-2-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]-9H-purin-9-yl]-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-furandiol

(2R,3R,4S,5S)-2-[2-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]-6-[(1-naphthalenylmethyl)amino]-9H-purin-9-yl]-5-(3-ethyl-5-isoxazolyl)tetrahydro-3,4-furandiol