Product
KO-539
CAT NO.:NC00526 |  CAS No.: 2134675-36-6 |  Purity: 97%        
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* Storage: Store long-term in a tightly closed container,in a cool and dry place.
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Product Details
Synonyms 4-Methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-1H-indole-2-carbonitrile
CAS 2134675-36-6 Molecular Weight 717.87
Catalog Number NC00526 MDL
Appearance Melting point
Purity 97% Boiling Point
Molecular Formula C33H42F3N9O2S2 Flash Point
Safety
GHS Pictograms
Signal Word Class
Precautionary Statements UN Number
Hazard Statements Packing Group
Description

KO-539 is a novel, once-daily, oral investigational drug candidate targeting the menin-KMT2A/MLL protein-protein interaction for treatment of genetically defined AML patients with high unmet need; In preclinical models, KO-539 inhibits the KMT2A/MLL protein complex and has downstream effects on HOXA9/MEIS1 expression. KO-539 has received Orphan Drug Designation from the U.S. Food and Drug Administration for the treatment of AML.

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Historical Records
CAS No. 2134675-36-6
Catalog Number NC00526
Purity 97%